Selective microstructure-size filters for non-invasive quantitative MRI

MILENA CAPIGLIONI; ANALIA ZWICK; PABLO JIMÉNEZ; GONZALO A. ALVAREZ

Congreso; ISMRM 2021; 2021

Extracting quantitative microstructure information of living-tissue by non-invasive imaging is anoutstanding challenge for understanding disease mechanisms. We introduce a method to makeselectively images of microstructure-sizes by probing molecule diffusion with MRI. It relies on designingdynamical control of nuclear spins to sense magnetization ?decay-shifts? rather than the commonly usedspin-echo decay-rates. The feasibility and performance of the method are illustrated with proof-of-principle experiments and simulations on typical size-distributions of white-matter in the mouse brain.These results position spin-echo decay-shifts as a promising MRI tool to perform non-invasive histologywithout assuming a microstructure distribution model.