INVESTIGADORES
RIGALLI Alfredo
congresos y reuniones científicas
Título:
A New Minimal Mathematical Model of the Endocrine System of Normal Rats Validated against Experimental Data.
Autor/es:
CAMPETELLI, GERMA; LOMBARTE, MERCEDES; BASULADO MARTA; RIGALLI ALFREDO
Lugar:
Córdoba
Reunión:
Congreso; Congreso Argentino de Informatica y Salud; 2011
Resumen:
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As
a common laboratory practice, rats are studied as biological models
for understanding human physiology. Even though, with the advent of
modern computer sciences, new methodologies appeared in medical
sciences like simulation and optimization to simplify and improve the
experimental work. With this background, a novel simulation model of
the endocrine system of Sprague Dawley rats is presented. It is a
simplified mathematical model composed of 3 differential equations
and 8 parameters that have been determined and validated with
experimental measures of plasma glucose and insulin alone by means of
calculus and optimization techniques. The results presented here are
a step before the development of a type I diabetic model of Sprague
Dawley rats.
