Regeneración y neurogénesis en la retina.

M. PAULA FAILLACE

Montevideo

Seminario; Seminario de la Facultad de Ciencias, Universidad Nacional de Montevideo, Uruguay. Invitada por los Dres. Flavio Zolessi y Francesco Rossi (Director en Montevideo del programa AMSUD-Pasteur).; 2010

Universidad Nacional de Montevideo. Instituto AMSUD-Pasteur.

Regeneration and growth that occurs in the adult teleost retina have been helpful in identifying molecular and cellular mechanisms underlying cell proliferation and differentiation. Damage to retinal cells can trigger retinal repair. Injured cells realease ATP to the extracellular millieu. The aim of this study was to investigate the role of the extracellular nucleotides, the enzymes that catalyzes their extracelullar hydrolysis and their specific receptors (P) on retinal regeneration. Nucleotides, particularly ADP action via P2Y1 receptors, are necessary to control cell-cycle activity to enhance progenitor cell proliferation during retinal repair and growth.