Epidemiological perspectives of amyloidosis in Argentina: results of an analysis of incidence and mortality in a population affiliated to a Medical Care Program

MARIA LOURDES POSADAS MARTINEZ; DELFINA CIRELLI; ADELA AGUIRRE; ELSA NUCIFORA

Simposio; International Symposium on Amyloidosis 2024; 2024

ID 108María Lourdes Posadas Martínez; Delfina Cirelli; Florencia De Florio; María Adela Aguirre; María Soledad Saez; Patricia Beatriz Sorroche; Erika Barbara Brulc; Elsa Mercedes Nucifora; Valeria Aliperti; Jimena Vicens; Marcelina Carretero.Submitting Author: Delfina Cirelli. Hospital Italiano de Buenos Aires. Ciudad Autónoma de Buenos Aires. Argentina.Main Body of the AbstractBackground: Data on the epidemiology of amyloidosis are scarce worldwide, making it difficult to understand its true incidence and mortality.Objective: To estimate the incidence and mortality rate of systemic amyloidosis in people affiliated to a Medical Care Program in Buenos Aires, Argentina.Materials & methods: Prospective cohort study. All affiliates to the Medical Care Program of the Hospital Italiano de Buenos Aires, and incident cases and deaths due to amyloidosis from the Institucional Amyloidosis Registry from January 1, 2011, to December 31, 2022, were included. Incidence and mortality rates were reported per million person-year with their respective 95% confidence intervals (95%CI). Crude, standardized, and stratified rates were determined.Results: During the study period, 1668182 person-year were at risk. The crude incidence rate was 63 (95%CI 52-76) and the crude mortality rate was 31 (95%CI 23-40) cases per million person-years. The ATTR wild-type amyloidosis subtype exhibited the highest rates, followed by AL amyloidosis. Men were more affected, especially from the age of 70 years onwards. Additionally, an increase in the incidence and mortality rate was observed throughout the period studied. The standardized incidence rate to the US population was 20 (95%CI 15-25) cases per million person-year.Summary & Conclusion: The results of this study indicate that amyloidosis remains a rare disease but has increased in incidence in recent years, especially in elderly people. This underlines the importance of further research in epidemiology for a better understanding of the pathology and its evolution.