Therapeutic potential of essential oils in tissue engineering

PEREZ RECALDE MERCEDES

Kalaburagi

Conferencia; Recent Advances in bio-nano composites for enhancing human health; 2024

Gulbarga University (Department of Botany)

The Tissue Engineering field combines chemistry, physics, and engineering to createartificial tissues for repairing damaged living tissues. Resorbable scaffolds areimplantable biomedical devices designed to temporarily replace damaged tissue andpromote restoration by encouraging cell proliferation while biodegrading. Among thechallenges in order to achieve successful scaffolds, it is of standing out theincorporation of active biomolecules that may take part on the process, giving thesecond and third generation of biomaterials for health.We will present the current research in Lab3Bio (Laboratory of Biomaterials,Biomechanics and Bioinstrumentation) regarding the utilisation of the biopolymerpolyhydroxybutyrate-co-hydroxyvalerate (PHBV) in developments for bone and skinregeneration and incorporating plan essential oils. These active blends are welknownbecause of their demonstrated properties such as antimicrobial, antiinflamatory orantioxidant. In our regard, the incorporation of essential oils with antibacterial activityaims to reduce infection risks at the surgical site, and decrease antibiotic usage in aworrying context of antibiotic resistance.Thoughout the presentation, we will see research using solvent cast and microparticlesmethod to incorporate essential oils into the polymer. But above all we will deepen inour line of 3D printed scaffolds for bone regeneration treated with a dip coating methodthat confer antimicrobial properties to the scaffolds using lavender essential oil. Afterthe incorporation of essential oils (AE), the release profile into the medium,antimicrobial concentrations, and cytotoxicity were characterized; all these aspects willbe discussed.