LEPTIN EFFECTS ON THE EXPRESSION OF RAC3 COACTIVATOR

CASTELLANOS IARA; ROSA, FRANCISCO DAMIÁN; LIRA, MARÍA CECILIA; BERNACCHIA JULIANA LOURDES; QUINTANILLA, MARÍA FLORENCIA; PALMA, ALEJANDRA GRACIELA; COSTAS M. A.; RUBIO M. F.

Congreso; LXVIII ANNUAL MEETING OF SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA; 2023

Adipocytes account for the largest proportion among the cells thatcomprise breast tissue. Although they are considered to be a criticalcell type in the tumor microenvironment of breast cancer, it is stillunclear the molecular mechanisms that control their behavior in thiscontext. We have demonstrated that the expression of the coacti-vator RAC3 decreases during adipogenesis and was increased inadipose tissue adjacent to breast tumors. Therefore, the aim of thiswork was to study if leptin was able to modulate RAC3 expression.From the systematic review of 20 papers, we confirmed the as-sociation between serum leptin levels and the presence of breastcancer in postmenopausal women (test for overall effect Z=11.98,p