EFEITO DO ANESTÉSICO NO MODELO MURINO DA INFECÇÃO PELO EHV-1 EFFECTS OF ANHESTETICS IN THE MURINE MODEL OF EHV-1 INFECTION

MATÍAS EÖRY1, CAROLINA ZANUZZI2, NADIA FUENTEALBA, JUAN PICCIONI, MARIELA SCROCHI, CECILIA GALOSI, EDUARDO GIMENO, CLAUDIO BARBEITO

Goiania

Congreso; XV ENAPAVE (Encontro Nacional de Patología Veterinaria I Congreso Brasileiro de Patología Veterinaria.; 2011

Sociedade Brasileira do Patologia Veterinaria

ABSTRACT During the development of the murine model of the Equine herpesvirosis due to Equid Herpesvirus 1 (EHV-1), different anesthetics were used. This model has provided information regarding several pathological aspects of the disease and repeats almost all the clinical signs of the affection in a similar way to the natural host. Despite this, the knowledge about the early events of the pulmonary immune response is confused, especially regarding the type and the number of immune cell populations present in the infection foci. We hypothesized that these differences are consequence of the interaction between the anesthetic compounds and the virus. In order to contrast this hypothesis, we experimentally infected mice with a unique EHV-1 strain under three different anesthetics and we described the lesions found in the