CONICET | Buscador de Institutos y Recursos Humanos

Introduction: The MUC1/Muc1 mucin (MUC1 in humans and Muc1 in others species) is a high molecular weight transmembrane glycoprotein expressed at the apical surface of most epithelia. It has been established that MUC1 expression coincides with the onset of epithelial sheet and glandular formation during embryonic development. Objective: To analyze Muc1 expression and tissue specific localization in different embryonic stages of the rat. Methodology: a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. specific localization in different embryonic stages of the rat. Methodology: a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 in others species) is a high molecular weight transmembrane glycoprotein expressed at the apical surface of most epithelia. It has been established that MUC1 expression coincides with the onset of epithelial sheet and glandular formation during embryonic development. Objective: To analyze Muc1 expression and tissue specific localization in different embryonic stages of the rat. Methodology: a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. specific localization in different embryonic stages of the rat. Methodology: a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. : The MUC1/Muc1 mucin (MUC1 in humans and Muc1 in others species) is a high molecular weight transmembrane glycoprotein expressed at the apical surface of most epithelia. It has been established that MUC1 expression coincides with the onset of epithelial sheet and glandular formation during embryonic development. Objective: To analyze Muc1 expression and tissue specific localization in different embryonic stages of the rat. Methodology: a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. specific localization in different embryonic stages of the rat. Methodology: a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Objective: To analyze Muc1 expression and tissue specific localization in different embryonic stages of the rat. Methodology: a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Methodology: a total of 8 embryos of each gestational stage (13 to 20 days of gestation), 8 neonates and 8 adults were included. By Immunohistochemistry, employing the anti-MUC1 CT33 antibody, the following tissues were analyzed: esophagus, stomach, small intestine, salivary gland, liver, pancreas, trachea, lung and kidney.. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Results: Muc1 expression was observed in the stomach, lung and kidney at the gestational age of 13 days (D13). In embryonic pancreas, Muc1 expression appeared at D14 stage. In small intestine, a strong reaction was observed from D15 while esophagus and trachea showed expression from D18. In all cases, the reaction was restricted to epithelial cells with a predominantly apical pattern. In the liver, a positive reaction was detected from D16, being the only organ analyzed which showed a cytoplasmic pattern. The ducts of the salivary glands showed reaction from D18 with an apical pattern; at D20, mucous and serous acini were distinguished and Muc1 expression was detected. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation. Discussion: In several of the organs analysed, rat Muc1 mucin was expressed in coincidence with epithelial differentiation which may suggest a possible role of this mucin during epithelia formation.

enviar mensaje