Changes in cervical endocannabinoidome in non-pregnant and pregnant mice.

MARVALDI, CAROLINA; CORREA, FERNANDO; JOHNSON, CLARE; MIRÓN GRANESE, AYELEN AIXA; AISEMBERG, JULIETA; FRANCHI, ANA MARIA; BRADSHAW, HEATHER B; WOLFSON, MANUEL LUIS

Mar del Plata

Congreso; Reunion anual de sociedades de biociencias; 2023

Sociedad Argentina de Investigación Clinica

The endocannabinoidome (eCBome) is a complex lipid signaling system composed of the endocannabinoids (eCB), eCB-related molecules, their receptors, and their metabolic enzymes. Despite cumulative evidence showing the important role of the eCBome in different aspects of female reproduction, little is known regarding their function in the physiopathology of the cervix. The cervix is a critical organ for pregnancy maintenance. Dynamic alterations in the structure of the cervical extracellular matrix drive flexibility and mechanical strength of the cervix throughout pregnancy, labor, and postpartum. Therefore, the aim of this work was to evaluate the participation of the eCBome in the cervical remodeling during gestation. No significant differences were observed between these groups for eCB receptors (CB1 and CB2) and NAPE-PLD protein levels. However, we found that FAAH protein levels were decreased in cervix from pregnant mice on day 15 of gestation when compared to non-pregnant mice (p