PIAS4, A NOVEL REGULATOR OF TAU HOMEOSTASIS

MARÍA CLARA SOKN; ANGEL RAMÓN TORRES MC COOK; VANINA GISELLE VELARDO; ROMINA PAULA GOBBINI; ALEJANDRA ATTORRESI; SERGIO SENIN; EDUARDO ARZT; TOMÁS FALZONE; ANA CLARA LIBERMAN

Mar del Plata

Congreso; LXVIII Reunión Anual de la Sociedad Argentina de Investigación Clínica; 2023

Tauopathies are neurodegenerative diseases characterized by dysregulation of tau homeostasis. Accumulating evidence points to an important role of the PIAS SUMO ligases as key regulators of severalproteins involved in neurodegeneration. The aim of this work was to evaluate the role of the PIAS family in the regulation of tau homeostasis. Using a Western blot (WB)-based screen in HT22 cells overexpressing human 2N4R WT tau (hTau) together with the PIAS family members, we observed a robust increase in total tau induced exclusively by PIAS4 (+0.75, p