Antioxidant effect of resveratrol administered with the consumption of enriched wine or as a dietary supplement in patients with risk factors for metabolic syndrome.

MARTINEZ SARRASAGUE, M; LAIRION F; CIMATO A; PASTOR R; MANFREDI Z; CHIESA I; PASTOR I; PASTOR E; RODRIGUEZ A; SAPORITO MAGRIÑA C; IERMOLI L; BAVASO C; CARBIA, C; TABORDA C; LAZAROWSKI A; IERMOLI R; REPETTO MG

Congreso; Reunión conjunta SAIC. SAB, AAFE & AACyTAL 2023. LXVIII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC), XXV Reunión Anual de la Sociedad Argentina de Biología (SAB), LV Reunión Anual de la Asociación Argentina de Farmacología Expe; 2023

Sociedad Argentina de Investigacion Clinica

Resveratrol (R) treatment improves the antioxidant response in cells and plasma of patients with risk factors of Metabolic Syndrome (MS) by protecting from inflammation and oxidative damage. Previous results indicated that R decreases oxygen consumption (∆O2) and peroxidation of lipids in PMN isolated of MS patients. The objective of this study is to compare the protective effect of R in patients with MS administered with resveratrol-enriched wine (REW) or as a dietary supplement. Voluntary patients with a diagnosis of MS (n=92) based on the diagnostic criteria of the National Cholesterol Education Program, Adult treatment Panel III, 2002 were supplemented 6 months with REW (n=30, age: 63 ± 10 years old, 150 mg/L), or 3 months with dietary R in tablets (n= 23, age: 68 ± 5 years old, 50 mg resveratrol, 25 mg alpha-tocopherol and 5 mg piperine) along with their usual treatment. Control was the patient himself in baseline conditions, avoiding interindividual variables and bioavailability of active principles. Venous blood was collected (53 patients), and biochemical markers were assessed at 0, 3 and 6 months of treatment in PMN, plasma and red blood cells: ∆O2, lipid oxidation (TBARS), protein oxidation (carbonyl protein, CO), catalase (CAT) and superoxide dismutase (SOD) activities, and glutathione (GSH) content. At 6 months of treatment, ∆O2 decreased with REW (56%, p