Metabolic and cardiovascular alterations induced in rats by high fat and fructose diets during growth can be attenuated by zinc supplementation

MEDINA AGUSTINA; PAEZ DIAMELA; POLERO FRANCO ; GAETTANI JUAN MANUEL; NOCETTI GABRIELA; MORIONDO MARISA; DOMÍNGUEZ JUANA; OLANO CAROLINA; ZAGO VALERIA; ELESGARAY ROSANA; CANIFFI CAROLINA; ARRANZ CRISTINA; TOMAT ANALÍA

Congreso; 2022 Annual Meeting of International Society for Heart Research. Latinoamerican Section (ISHR LAT).; 2022

Introduction: High fat high fructose diet induces metabolic disorders in adult life. In previous studies we demonstrated that zinc has antioxidant properties and can regulate metabolism.Objective: To evaluate the effects of postnatal zinc supplementation on systolic blood pressure (SBP), retroperitoneal adipose tissue (RPAT) and intermediate metabolism in adult male Wistar rats fed a high fat and fructose diet during growth.Methodology: Male wistar rats fed since weaning (21 days) to adult life (81 days): Cc: zinc control diet (30 ppm); Cgf: zinc control-high fat diet and fructose 10% in drinking water; Zgf: zinc supplemented (190 ppm)-high fat diet and fructose 10% in drinking water. At day 81, we determined SBP, metabolic profile, RPAT morphology and blood oxidative stress. N=5 for each group. Two-way Anova, test post-hoc: Bonferroni: ***p