Association of metabolic syndrome with male reproductive status in the second generation

GIACCAGLI, M; HERZFELD JD, ; WEIGEL MUÑOZ M,; CUASNICÚ PS; DA ROS VG, ; COHEN DJ

Congreso; Reunión Anual de Sociedades de Biociencia (SAIC, SAI, FAIC); 2022

The prevalence of metabolic syndrome (MetS) has increased in alarming proportions. Its prevalence has also increased in younger populations, coinciding with reproductive age and being a risk factor for fertility disorders. MetS has been defined as a set of physiopathological disorders comprising the increase of at least three of the following parameters: abdominal obesity, blood pressure, triglycerides, cholesterol and fasting glucose. Male fertility seems less susceptible to MetS than female fertility, being probable that males with MetS remain competent to father children after natural conceiving or following a successful assisted-reproduction technique. Based on this, the aim of this study is evaluate the effect of MetS on the male reproductive status of their offspring in a murine model. To this end, the offspring of male C57BL/6J mice that had been fed a control diet (CD, 6% fat) or a high-fat diet (HFD, 34% fat) (F0) mice were randomly assigned into two groups to receive either: CD or HFD (F1). However, as both HFD groups consumed less total food than CD males (p