SPEXIN ADIPOKINE MODULATE INGUINAL WHITE ADIPOSE TISSUE THERMOGENESIS UPON COLD EXPOSURE

GAMBARO, S.E.; ZUBIRÍA, M.G.; GIORDANO ALEJANDRA; HARNICHAR, EZEQUIEL; CASTRO, PATRICIA; GIOVAMBATTISTA, A.

Congreso; LXVII Reunion Anual de la Sociedad de Investigaciones Clinicas; 2022

SAIC; SAI; SAFIS

Spexin is an anorexigenic adipokine that has multiple physiological function such as anti-obesogenic properties, anxiolytic, among others but there are not current information about SPX role on white adipose tissue (AT) thermogenesis. So, male mice were treated or not (CTR) with SPX for 10 days (29ug/kg/day; SPX) and at day 3 some animals were kept at RT and other at 4°C during 7 days (CTR-C; SPX-C) for thermogenesis induction. In this study, Inguinal AT was collected and processed for different determinations. Metabolic profile was previously reported. mRNA expression of UCP1, SPX and its receptor GALR2 showed interaction between variables (Two-way-anova; Cold x SPX). UCP1 post test showed an increase in CTR-C group vs. CTR and decreased in SPX-C vs. CTR-C (P