INIBIBB 05455
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BAHIA BLANCA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
The anticonvulsive drug oxcarbazepine is a nicotinic acetylcholine recptor channel blocker
Autor/es:
VALLÉS, A.S.; BARRANTES, F.J.
Lugar:
Puerto Madryn, Chubut.
Reunión:
Congreso; XLVI Reunión Anual de la Sociedad Argentina de Investigación Bioquímica y Biología Molecular; 2010
Institución organizadora:
Sociedad Argentina de Investigación Bioquímica y Biología Molecular
Resumen:
Summary Objective: To assay the effect of oxcarbazepine, an anticonvulsive and mood-stabilizing drug used in the treatment of some forms of epilepsy, on the nicotinic acetylcholine receptor (AChR). Methods: Electrophysiological recordings using the single-channel recording patch-clamp technique to evaluate the AChR function in the presence/absence of different concentrations of oxcarbazepine Results: The main effects caused by the drug were a concentration-dependent decrease in channel mean open time, an increase in one of the components of the mean burst duration, tburst, concomitant with a decrease in the duration of the second tburst component, and the appearance of a new closed-channel component. The duration of the latter remained constant in the range of concentrations tested, although its relative contribution showed concentration-dependent behavior. Conclusion: It is concluded that oxcarbazepine blocks the AChR channel, allowing it to reopen quickly, through a mechanism compatible with that of channel blockers.
