CIHIDECAR 12529
CENTRO DE INVESTIGACIONES EN HIDRATOS DE CARBONO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
PEGASUS: A NOVEL DOPAMINE AGONIST WITH NEUROPROTECTIVE EFFECT
Autor/es:
AGUSTIN PERNICONE; MARTIN LUONG; FLORENCIA GONZÁLEZ-LIZÁRRAGA; OSCAR VARELA; ROSANA CHEHIN; ESTEBAN VERA PINGITORE; ADRIANA A. KOLENDER; SILVINA CHAVES; VERÓNICA E. MANZANO; CESAR ÁVILA; RODRIGO TOMAS-GRAU; DIEGO PLOPER
Lugar:
Paris
Reunión:
Congreso; Federation of European Neuroscience Societies; 2022
Institución organizadora:
FENS (Federation of European Neuroscience Societies)
Resumen:
Continuous and safe delivery of dopamine (DOPA) across the blood brain barrier (BBB) is a main obstacle for successful substitution therapy in Parkinson´s disease. Our aim is to take advantage of the well-known capacity of doxycycline (DOXY) to cross the BBB1, together with its neuroprotective activity2 , in order to obtain a DOXY-DOPA hybrid molecule, which we call Pegasus, with potential application in Parkinson´s disease.
