Optimization of magnetic hyperthermia and catalytic activity of multifunctional nanoparticles

FERNANDO FABRIS; NAHUEL NUÑEZ; MORENO MALDONADO, ANA CAROLINA; VASQUEZ MANSILLA, MARCELO; TEOBALDO TORRES MOLINA; RAINERI, MARIANA; TROIANI, HORACIO E.; TOBIA, DINA; GOYA, GERARDO F.; ZYSLER, ROBERTO D.; ENIO LIMA JR.; WINKLER, ELIN L.

Conferencia; 11th International Conference on Fine Particles Magnetism (ICFPM 2022); 2022

The magnetic nanoparticles (MNPs) are widely studied due to the unique possibility of fine tuning its physicochemical properties that allow it to adjust its performance according to the different requirements. The advances in the fabrication process also permit combining different functionalities in the core and shell which gives enormous versatility to these systems to develop new multifunctional nanoparticles with controlled response. In fact, the use of magnetic nanoparticles based on iron oxides is currently extended in different application fields as biology, medicine, environment, energy and engineering.[1]One of the research areas of interest in medicine and environmental remediation is the optimization and synergy between magnetic hyperthermia and the catalytic activity of these systems.[2,3] By varying the size and composition of the MNPs the effective magnetic anisotropy can be tuned, in this way the Brown or Néel magnetic relaxation mechanism can be selected and the heating efficiency in presence of alternating magnetic field can be optimized. The ferrite nanoparticles also present catalytic activity where highly oxidative free radicals are generated. The radical species formed during heterogeneous Fenton reactions, have an effective oxidative ability that can induce oxidative stress and could promote tumor cell death in cancer therapies or also degradation of organic pollutants or dye for environmental remediation.In this talk I will present the steps followed by our research group in order to design and fabricate iron oxide based nanoparticles for tuning their magnetic anisotropy. In this way, the heating efficiency by the Néel relaxation mechanism was selected, even when the NPs were fixed in a hydroxyapatite matrix.[4,5,6] We also analyse the free radical production catalysed by different ferrite nanoparticles, by Electron Paramagnetic Resonance spectroscopy, and their dependence with the nanoparticles surface to volume ratio, surface composition and also the pH and temperature of the media.[7,8] The synergy among the magnetic and catalytic properties of these nanoparticles makes them very promising materials to further applications in nanomedicine and in environmental remediation to degradation of organic contaminants.AcknowledgementsThe authors acknowledge financial support from Argentinian governmental agency ANPCyT (Project Nos. PICT-2019-02059 and PICT-2018-02565) and the EU-Commission (Project Nos. H2020-MSCA-RISE-2020 101007629-NESTOR).References[1] D. Peddis, S. Laureti and D. Fiorani. New Tends in Nanoparticles Magnetism. Springer Series in Materials Science 2021. [2] Y.Huang, J. Ren, and X. Qu. Chem. Rev. 119 (2019) 4357.[3] G.F. Goya et al. J. Appl. Phys. 130, 190903 (2021).[4] N. Nuñez, et al. J. of Alloys and Comp. (2022).[5] F. Fabris, et al. Nanotech. 32 (2021) 065703 (11pp)[6] F.Fabris, et al Nanoscale 11 (2019) 3164.[7] A. C. Moreno Maldonado et al. J. of Phys. Chem. C 123 (2019) 20617.[8] M. Raineri, et al. Nanoscale 11 (2019) 18393.