INVESTIGADORES
POMILIO Carlos Javier
congresos y reuniones científicas
Título:
Astroglial alterations from early to late stages in a model of Alzheimer's Disease: evidence of autophagy involvement in Amyloid-beta internalization
Autor/es:
POMILIO CARLOS; GOROJOD ROXANA; VINUESA ÁNGELES; ALAIMO AGUSTINA; APARICIO EVANGELINA; TODERO MARÍA FLORENCIA; KOTLER MÓNICA; BEAUQUIS JUAN; SARAVIA FLAVIA
Lugar:
Mar del Plata
Reunión:
Congreso; Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2015
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias
Resumen:
Alzheimer?s disease (AD) is the principal cause of dementia in the elderly. One histopathological hallmark of AD is the presence of senile plaques, extracellular deposits principally composed of amyloid-β (Aβ) peptides, which are normally surrounded by reactive glia. We studied early alterations in hippocampal astrocytes and their progression during the degenerative process in PDAPP transgenic mice, a model of AD. At 3 months of age, before plaques formation, we found less number of GFAP+ astrocytes in the stratum radiatum under CA1 (p
