Evidence of autophagy dysregulation on microglial cells in the context of Alzheimer?s disease using in vitro and in vivo models

CARLOS POMILIO; AGUSTINA ALAIMO; ROXANA GOROJOD; ÁNGELES VINUESA; JESSICA PRESA; MELISA BENTIVEGNA; SOLEDAD PORTE ALCÓN; JUAN BEAUQUIS; JUAN BONIFACINO; MÓNICA KOTLER; FLAVIA SARAVIA

Simposio; The role of glia in health and disease of the neruvous system: clinical and basic science walking together; 2017

Alzheimer?s disease (AD) is the principal cause of dementia in the elderly. A recognized hallmark of AD is the aggregation of Amyloid-β peptides (Aβ) into senile plaques, frequently surrounded by hypertrophied glial cells. We studied microglial alterations in the hippocampus of PDAPP mice, a well-established transgenic model of AD. Before detection of plaques in the brain, we found an early increase in the Iba1+ soma related area and activation score (p