ANTITUMORAL AND IMMUNOMODULATORY ROLE OF HISTAMINE IN BREAST CANCER

NICOUD, M.B.; STERLE, H.A.; MASSARI, NOELIA A.; TÁQUEZ DELGADO, MÓNICA A.; FORMOSO, K; HERRERO DUCLOUX, MARÍA V.; MARTINEL LAMAS, D.J.; MEDINA, V.A.

Mar del Plata

Congreso; LXIII Reunión Anual de la SAIC, Sociedad Argentina de Investigación Clínica; 2018

Sociedad Argentina de Investigación Clínica

􀀬􀁗􀀃􀁌􀁖􀀃􀁚􀁈􀁏􀁏􀀃􀁎􀁑􀁒􀁚􀁑􀀃􀁗􀁋􀁄􀁗􀀃􀁋􀁌􀁖􀁗􀁄􀁐􀁌􀁑􀁈􀀃􀁌􀁖􀀃􀁄􀀃􀁎􀁈􀁜􀀃􀁕􀁈􀁊􀁘􀁏􀁄􀁗􀁒􀁕􀀃􀁒􀁉􀀃􀁌􀁐􀁐􀁘􀁑􀁈􀀃􀁆􀁈􀁏􀁏􀀃􀁉􀁘􀁑􀁆-tions and it also modulates cancer cell proliferation. The aim of this􀁚􀁒􀁕􀁎􀀃􀁚􀁄􀁖􀀃􀁗􀁒􀀃􀁌􀁑􀁙􀁈􀁖􀁗􀁌􀁊􀁄􀁗􀁈􀀃􀁗􀁋􀁈􀀃􀁈􀁉􀁉􀁈􀁆􀁗􀀃􀁒􀁉􀀃􀁋􀁌􀁖􀁗􀁄􀁐􀁌􀁑􀁈􀀃􀁄􀁑􀁇􀀃􀁌􀁗􀁖􀀃􀀫􀀗􀀃􀁕􀁈􀁆􀁈􀁓􀁗􀁒􀁕􀀃􀀋􀀫􀀗􀀵􀀌􀀃􀁄􀁊􀁒􀁑􀁌􀁖􀁗􀀃􀀋􀀭􀀱􀀭􀀕􀀛􀀙􀀔􀀓􀀕􀀗􀀗􀀌􀀃􀁒􀁑􀀃􀁗􀁘􀁐􀁒􀁘􀁕􀀃􀁊􀁕􀁒􀁚􀁗􀁋􀀃􀁄􀁑􀁇􀀃􀁌􀁑􀀃􀁗􀁋􀁈􀀃􀁌􀁐􀁐􀁘􀁑􀁈􀀃􀁗􀁘􀁐􀁒􀁘􀁕􀀃􀁐􀁌􀁆􀁕􀁒􀁈􀁑􀁙􀁌􀁕􀁒􀁑􀁐􀁈􀁑􀁗􀀃􀁄􀁖􀀃􀁄􀀃􀁚􀁋􀁒􀁏􀁈􀀏􀀃􀁌􀁑􀀃􀁄􀀃􀁗􀁕􀁌􀁓􀁏􀁈􀀃􀁑􀁈􀁊􀁄􀁗􀁌􀁙􀁈􀀃􀁅􀁕􀁈􀁄􀁖􀁗􀀃􀁆􀁄􀁑-cer (TNBC) syngeneic model developed in immunocompetent mice.􀀷􀁘􀁐􀁒􀁘􀁕􀁖􀀃􀁒􀁉􀀃􀁗􀁋􀁈􀀃􀀷􀀱􀀥􀀦􀀃􀁆􀁈􀁏􀁏􀀃􀁏􀁌􀁑􀁈􀀃􀀗􀀷􀀔􀀃􀁚􀁈􀁕􀁈􀀃􀁈􀁖􀁗􀁄􀁅􀁏􀁌􀁖􀁋􀁈􀁇􀀃􀁌􀁑􀀃􀀥􀁄􀁏􀁅􀀒􀁆􀀃􀁐􀁌􀁆􀁈􀀑􀀃􀀷􀁕􀁈􀁄􀁗􀁐􀁈􀁑􀁗􀁖􀀃􀁈􀁐􀁓􀁏􀁒􀁜􀁈􀁇􀀝􀀃􀁋􀁌􀁖􀁗􀁄􀁐􀁌􀁑􀁈􀀃􀀋􀀔􀀃􀁒􀁕􀀃􀀘􀀃􀁐􀁊􀀒􀁎􀁊􀀌􀀃􀁄􀁑􀁇􀀃􀀭􀀱􀀭􀀕􀀛􀀙􀀔􀀓􀀕􀀗􀀗􀀃􀀋􀀔􀀃 􀁒􀁕􀀃 􀀘􀀃 􀁐􀁊􀀃 􀁎􀁊􀀌􀀑􀀃 􀀵􀁈􀁖􀁘􀁏􀁗􀁖􀀃 􀁖􀁋􀁒􀁚􀀃 􀁗􀁋􀁄􀁗􀀃 􀁋􀁌􀁖􀁗􀁄􀁐􀁌􀁑􀁈􀀃 􀁗􀁕􀁈􀁄􀁗􀁐􀁈􀁑􀁗􀀃 􀀋􀀘􀀃 􀁐􀁊􀀒􀁎􀁊􀀌􀀃􀁕􀁈􀁇􀁘􀁆􀁈􀁖􀀃􀁗􀁘􀁐􀁒􀁘􀁕􀀃􀁊􀁕􀁒􀁚􀁗􀁋􀀃􀁐􀁒􀁕􀁈􀀃􀁈􀁉􀁉􀁈􀁆􀁗􀁌􀁙􀁈􀁏􀁜􀀃􀁗􀁋􀁄􀁑􀀃􀀭􀀱􀀭􀀕􀀛􀀙􀀔􀀓􀀕􀀗􀀗􀀑􀀃􀀫􀁌􀁖􀁗􀁄-mine but not the agonist increases tumour apoptosis and it reduces the number of intratumoural vessels. Histamine also reduces immunosuppressionthrough the modulation of the tumour microenvironment,as it increases the tumour secretion of IFN gamma andreduces the number of T regulatory (Treg) lymphocytes in lymphnodes and spleen.􀀤􀀃 􀁏􀁒􀁚􀁈􀁕􀀃 􀁆􀁒􀁑􀁆􀁈􀁑􀁗􀁕􀁄􀁗􀁌􀁒􀁑􀀃 􀀋􀀔􀀃 􀁐􀁊􀀒􀁎􀁊􀀌􀀃 􀁒􀁉􀀃 􀀭􀀱􀀭􀀕􀀛􀀙􀀔􀀓􀀕􀀗􀀗􀀃 􀁕􀁈􀁇􀁘􀁆􀁈􀁖􀀃 􀁗􀁘􀁐􀁒􀁘􀁕􀀃􀁖􀁌􀁝􀁈􀀃􀁚􀁋􀁌􀁏􀁈􀀃􀁑􀁒􀀃􀁌􀁐􀁐􀁘􀁑􀁒􀁐􀁒􀁇􀁘􀁏􀁄􀁗􀁒􀁕􀁜􀀃􀁈􀁉􀁉􀁈􀁆􀁗􀁖􀀃􀁄􀁕􀁈􀀃􀁒􀁅􀁖􀁈􀁕􀁙􀁈􀁇􀀃􀁌􀁑􀀃􀁗􀁋􀁈􀀃􀁌􀁐􀁐􀁘􀁑􀁈􀀃cell subsets studied. In contrast, a higher concentration (5 mg/kg) is􀁑􀁒􀁗􀀃 􀁄􀁅􀁏􀁈􀀃 􀁗􀁒􀀃 􀁇􀁈􀁆􀁕􀁈􀁄􀁖􀁈􀀃 􀁗􀁘􀁐􀁒􀁘􀁕􀀃 􀁊􀁕􀁒􀁚􀁗􀁋􀀃 􀁓􀁕􀁒􀁅􀁄􀁅􀁏􀁜􀀃 􀁅􀁈􀁆􀁄􀁘􀁖􀁈􀀃 􀁒􀁉􀀃 􀁗􀁋􀁈􀀃 􀁌􀁐-munosuppressive effect produced in the tumour microenvironment,􀁖􀁋􀁒􀁚􀁌􀁑􀁊􀀃􀁌􀁑􀁆􀁕􀁈􀁄􀁖􀁈􀁇􀀃􀁏􀁈􀁙􀁈􀁏􀁖􀀃􀁒􀁉􀀃􀁌􀁑􀁗􀁈􀁕􀁏􀁈􀁘􀁎􀁌􀁑􀀃􀀋􀀬􀀯􀀌􀀐􀀔􀀓􀀃􀁄􀁑􀁇􀀃􀁇􀁈􀁆􀁕􀁈􀁄􀁖􀁈􀁇􀀃􀁏􀁈􀁙􀁈􀁏􀁖􀀃􀁒􀁉􀀃 􀀬􀀩􀀱􀑜􀀃 􀁌􀁑􀀃 􀁗􀁘􀁐􀁒􀁘􀁕􀁖􀀃 􀁄􀁑􀁇􀀃 􀁌􀁑􀁆􀁕􀁈􀁄􀁖􀁈􀁇􀀃 􀁌􀁑􀃀􀁏􀁗􀁕􀁄􀁗􀁌􀁑􀁊􀀃 􀀷􀁕􀁈􀁊􀀃 􀁆􀁈􀁏􀁏􀁖􀀃 􀁌􀁑􀀃 􀁗􀁘􀁐􀁒􀁘􀁕􀀃draining lymph nodes. These results highlight the critical interplay􀁅􀁈􀁗􀁚􀁈􀁈􀁑􀀃􀁗􀁘􀁐􀁒􀁘􀁕􀀃􀁆􀁈􀁏􀁏􀁖􀀃􀁄􀁑􀁇􀀃􀁋􀁒􀁖􀁗􀀃􀁌􀁐􀁐􀁘􀁑􀁈􀀃􀁕􀁈􀁖􀁓􀁒􀁑􀁖􀁈􀀃􀁗􀁋􀁄􀁗􀀃􀁇􀁈􀁗􀁈􀁕􀁐􀁌􀁑􀁈􀀃􀁗􀁋􀁈􀀃clinical therapeutic outcomes and suggest that histamine is a key􀁓􀁏􀁈􀁌􀁒􀁗􀁕􀁒􀁓􀁌􀁆􀀃􀁐􀁈􀁇􀁌􀁄􀁗􀁒􀁕􀀃􀁚􀁌􀁗􀁋􀀃􀁗􀁋􀁈􀁕􀁄􀁓􀁈􀁘􀁗􀁌􀁆􀀃􀁅􀁈􀁑􀁈􀃀􀁗􀁖􀀃􀁌􀁑􀀃􀀷􀀱􀀥􀀦􀀑