TPGS BASED 99MTC NANO RADIOPHARMACEUTICALS: POTENTIAL APPLICATION IN BREAST CANCER DIAGNOSIS

TESAN, F; PORTILLO, M; GIAQUINTA DIEGO; NICOUD, MB; MORETTON, MARCELA A.; ZUBILLAGA, MARCELA; CHIAPPETTA, DIEGO A.; MEDINA, V.A.; SALGUEIRO, MARÍA J.

Mar del Plata

Congreso; LXIII Reunión Anual de la SAIC, Sociedad Argentina de Investigación Clínica; 2018

Sociedad Argentina de Investigación Clínica

There is only one useful SPECT radiopharmaceutical (99mTc-sesta-􀁐􀁌􀁅􀁌􀀌􀀃􀁉􀁒􀁕􀀃􀁅􀁕􀁈􀁄􀁖􀁗􀀃􀁆􀁄􀁑􀁆􀁈􀁕􀀃􀁇􀁌􀁄􀁊􀁑􀁒􀁖􀁌􀁖􀀃􀁄􀁑􀁇􀀃􀁉􀁒􀁏􀁏􀁒􀁚􀀃􀁘􀁓􀀃􀁄􀁑􀁇􀀃􀁌􀁗􀁖􀀃􀁘􀁗􀁌􀁏􀁌􀁗􀁜􀀃􀁆􀁄􀁕􀁕􀁌􀁈􀁖􀀃􀁚􀁌􀁗􀁋􀀃􀁖􀁒􀁐􀁈􀀃􀁏􀁌􀁐􀁌􀁗􀁄􀁗􀁌􀁒􀁑􀁖􀀑􀀃􀀲􀁘􀁕􀀃􀁄􀁌􀁐􀀃􀁚􀁄􀁖􀀃􀁗􀁒􀀃􀁈􀁙􀁄􀁏􀁘􀁄􀁗􀁈􀀃􀁗􀁋􀁈􀀃􀁓􀁈􀁕􀁉􀁒􀁕􀁐􀁄􀁑􀁆􀁈􀀃􀁒􀁉􀀃three micellar 99m􀀷􀁆􀀃 􀁑􀁄􀁑􀁒􀀃 􀁕􀁄􀁇􀁌􀁒􀁓􀁋􀁄􀁕􀁐􀁄􀁆􀁈􀁘􀁗􀁌􀁆􀁄􀁏􀁖􀀃 􀀋􀁌􀀐􀀷􀀳􀀪􀀶􀀞􀀃 􀁌􀁌􀀐􀀃 􀀷􀀳􀀪􀀶􀀃􀁄􀁑􀁇􀀃 􀀶􀁒􀁏􀁘􀁓􀁏􀁘􀁖􀂊􀀞􀀃 􀁌􀁌􀁌􀀐􀀃 􀀷􀀳􀀪􀀶􀀃 􀁄􀁑􀁇􀀃 􀀶􀁒􀁏􀁘􀁓􀁏􀁘􀁖􀂊􀀃 􀁚􀁌􀁗􀁋􀀃 􀁊􀁏􀁘􀁆􀁒􀁖􀁈􀀌􀀃 􀁄􀁖􀀃 􀁕􀁄􀁇􀁌􀁒-􀁌􀁖􀁒􀁗􀁒􀁓􀁌􀁆􀀃 􀁌􀁐􀁄􀁊􀁌􀁑􀁊􀀃 􀁓􀁕􀁒􀁅􀁈􀁖􀀑􀀃 􀀵􀁄􀁇􀁌􀁒􀁏􀁄􀁅􀁈􀁏􀁌􀁑􀁊􀀃 􀁚􀁄􀁖􀀃 􀁓􀁈􀁕􀁉􀁒􀁕􀁐􀁈􀁇􀀃 􀁅􀁜􀀃 􀁇􀁌􀁕􀁈􀁆􀁗􀀃􀁐􀁈􀁗􀁋􀁒􀁇􀀃 􀁄􀁑􀁇􀀃 􀁄􀀃 􀁖􀁜􀁑􀁊􀁈􀁑􀁈􀁌􀁆􀀃 􀁒􀁕􀁗􀁋􀁒􀁗􀁒􀁓􀁌􀁆􀀃 􀁐􀁒􀁇􀁈􀁏􀀃 􀁒􀁉􀀃 􀀥􀀤􀀯􀀥􀀒􀁆􀀃 􀁐􀁌􀁆􀁈􀀃 􀁌􀁑􀁍􀁈􀁆􀁗-􀁈􀁇􀀃 􀁚􀁌􀁗􀁋􀀃 􀀗􀀷􀀔􀀃 􀁆􀁈􀁏􀁏􀁖􀀏􀀃 􀁚􀁄􀁖􀀃 􀁘􀁖􀁈􀁇􀀃 􀁉􀁒􀁕􀀃 􀁖􀁆􀁌􀁑􀁗􀁌􀁊􀁕􀁄􀁓􀁋􀁌􀁆􀀃 􀁇􀁌􀁄􀁊􀁑􀁒􀁖􀁌􀁖􀀃 􀁈􀁙􀁄􀁏􀁘􀁄􀁗􀁌􀁒􀁑􀀃􀁚􀁌􀁗􀁋􀀃􀁄􀀃􀁊􀁄􀁐􀁐􀁄􀀃􀁆􀁄􀁐􀁈􀁕􀁄􀀑􀀃􀀷􀁋􀁈􀀃􀁘􀁓􀁗􀁄􀁎􀁈􀁖􀀃􀁙􀁌􀁖􀁘􀁄􀁏􀁌􀁝􀁈􀁇􀀃􀁌􀁑􀀃􀁗􀁋􀁈􀀃􀁌􀁐􀁄􀁊􀁈􀁖􀀃􀁚􀁈􀁕􀁈􀀃validated by biological distribution measuring radioactivity accumulationin organs of interesr by Solid Scintillation Counter. Nano radio-􀁓􀁋􀁄􀁕􀁐􀁄􀁆􀁈􀁘􀁗􀁌􀁆􀁄􀁏􀁖􀀃􀁖􀁌􀁝􀁈􀁖􀀃􀁚􀁈􀁕􀁈􀀃􀁐􀁈􀁄􀁖􀁘􀁕􀁈􀁇􀀃􀁅􀁜􀀃􀀧􀁜􀁑􀁄􀁐􀁌􀁆􀀃􀀯􀁌􀁊􀁋􀁗􀀃􀀶􀁆􀁄􀁗􀁗􀁈􀁕􀁌􀁑􀁊􀀃􀁄􀁗􀀃 􀀕􀀘􀂃􀀃 􀁄􀁑􀁇􀀃 􀀖􀀚􀂃􀀦􀀑􀀃 􀀷􀀳􀀪􀀶􀀃 􀁄􀁑􀁇􀀃 􀀶􀁒􀁏􀁘􀁓􀁏􀁘􀁖􀂊􀀃 􀁕􀁄􀁇􀁌􀁒􀁓􀁋􀁄􀁕􀁐􀁄􀁆􀁈􀁘􀁗􀁌􀁆􀁄􀁏􀀃 􀁚􀁄􀁖􀀃􀁗􀁋􀁈􀀃 􀁒􀁑􀁏􀁜􀀃 􀁒􀁑􀁈􀀃 􀁗􀁋􀁄􀁗􀀃 􀁄􀁏􀁏􀁒􀁚􀁈􀁇􀀃 􀁖􀁆􀁌􀁑􀁗􀁌􀁊􀁕􀁄􀁓􀁋􀁌􀁆􀀃 􀁙􀁌􀁖􀁘􀁄􀁏􀁌􀁝􀁄􀁗􀁌􀁒􀁑􀀃 􀁒􀁉􀀃 􀁗􀁋􀁈􀀃 􀁗􀁘􀁐􀁒􀁕􀀑􀀃􀀱􀁄􀁑􀁒􀀃 􀁕􀁄􀁇􀁌􀁒􀁓􀁋􀁄􀁕􀁐􀁄􀁆􀁈􀁘􀁗􀁌􀁆􀁄􀁏􀁖􀀃 􀁖􀁌􀁝􀁈􀁖􀀃 􀁌􀁑􀁆􀁕􀁈􀁄􀁖􀁈􀁇􀀃 􀁄􀁗􀀃 􀀖􀀚􀂃􀀦􀀃 􀁉􀁒􀁕􀀃 􀁖􀁜􀁖􀁗􀁈􀁐􀀃 􀁌􀁌􀀃and iii (more drastically for the latter). Biological distribution studies􀁖􀁋􀁒􀁚􀁈􀁇􀀃􀁘􀁓􀁗􀁄􀁎􀁈􀀃􀁙􀁄􀁏􀁘􀁈􀁖􀀃􀁗􀁋􀁄􀁗􀀃􀁅􀁄􀁆􀁎􀁈􀁇􀀃􀁘􀁓􀀃􀁖􀁆􀁌􀁑􀁗􀁌􀁊􀁕􀁄􀁓􀁋􀁌􀁆􀀃􀁕􀁈􀁖􀁘􀁏􀁗􀁖􀀃􀁉􀁒􀁕􀀃􀁈􀁄􀁆􀁋􀀃radiopharmaceutical assayed. In conclusion, mixed system of TPGSand Soluplus® stands as a potential candidate to be used in breastcancer imaging diagnosis.