CONICET | Buscador de Institutos y Recursos Humanos

Canine Visceral Leishmaniasis (CVL) and Human Visceral Leishmaniasis (HVL) are amongthe vector-borne parasitic diseases with the greatest impact on public and veterinary healthin the world, and are endemic in the province of Misiones, northeastern Argentina. The mainurban reservoir in America and much of Europe for Leishmania infantum is the dog. Theprotozoan is transmitted in our continent mainly by the bite of sandflies of the speciesLutzomyia longipalpis and also between dogs by vertical and venereal transmission. Inaddition to being a highly lethality global zoonosis, CVL is a disease that is difficult tomanage due to its complexity and the wide variety of clinical manifestations, which rangefrom asymptomatic dogs to severe symptoms. There are no preventive drugs against VL nora vaccine in use for humans or canines that has demonstrated effectiveness as a preventionor control tool in collective health, and although the insect Lu. longipalpis is susceptible tohousehold insecticides, its application has not shown effectiveness to interrupt transmission.There are insecticide repellent collars impregnated with pyrethroids for dogs, which antifeeding effectiveness extends for periods of 6 to 12 months, but the high acquisition coststranslate into little acceptance and adoption by dog owners in endemic areas. In turn, the lowsensitivities and failures in timely diagnosis, added to the high rates of dispersion due to pettransit and trafficking, make it difficult to manage infected dogs. In Misiones, a series ofstudies were carried out in different locations, and the results of surveys, statistical models,and cartographic outputs were used to evaluate the prevalence, spatial distribution, andfactors associated with CVL. These and other epidemiological aspects of CVL in an endemicarea of Argentina will be addressed, presenting the main challenges for the prevention andcontrol of this parasitosis.

enviar mensaje