Correlation between biomarkers of oxidative stress and degree of cognitive impairment in patients with leukoaraiosis and probable Alzheimer's disease.

CIMATO A; MARTINEZ SARRASAGUE, M; LAIRION F; SAPORITO MAGRIÑÁ, C; SERRA J; MARSCHOFF E ; OUDKERK L; BIANCHI GA; DOMINGUEZ R; REPETTO M

Congreso; Reunión conjunta SAIC. SAI & FAIC, SAFIS 2022. LXVII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC), lXX Reunión Anual de la Sociedad Argentina de Inmunología (SAI) & 3er Congreso Franco-Argentino de Inmunología (FAIC), Reunión Anu; 2022

Oxidative stress (OS) and oxidative damage (OD) are associated to the etiopathogenesis of Leukoaraiosis (L) and Alzheimer disease (A). The aim of this work was to evaluate whether OS markers in the blood of patients with L and A correlate with the degree of cognitive impairment (CI). Methods: OS biomarkers: carbonylated proteins (CO), oxidized lipids (TBARS), superoxide dismutase (SOD), catalase (CA), total (GSHt), reduced (GSH), and oxidized (GSSG) glutathione (by spectrophotometry), and IL-6 (by ELISA) were determined in the blood of elderly patients (75±6 years): 17 with a diagnosis of L (magnetic resonance imaging, brain computed tomography and Fasekas (F) cognitive test), 16 with A (neurological and cognitive tests: Clinical Dementia Rating (CDR)) and 17 healthy subjects (controls, C). The correlation between parameters was evaluated by Spearman coefficient (r). Results: In L, the advancement of CI correlates with age (r:0.38). CO increased in plasma from L (F2) and A (CDR2), SOD increased in L and A (p