BECAS
NICOLA CANDIA Alejandro Javier
congresos y reuniones científicas
Título:
IMPACT OF IDH MUTATIONS ON THE IMMUNOLOGICAL LANDSCAPE OF GLIOMAS: A TCGA META-ANALYSIS BASED ON THE 2021 WHO CLASSIFICATION OF BRAIN TUMOURS
Autor/es:
GONZALEZ, NAZARENO; ASAD, ANTONELA S; GÓMEZ ESCALANTE, JOSÉ; AGUDELO, JORGE A. PEÑA; NICOLA CANDIA, ALEJANDRO J; GARCIA FALLIT, MATÍAS; SEILICOVICH, ADRIANA; CANDOLFI, MARIANELA
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión anual de la SAIC; 2021
Institución organizadora:
SAIC
Resumen:
Mutations in the enzyme isocitrate dehydrogenase genes (mIDH) are currently used to classify diffuse gliomas, the most common malignant primary brain tumours in adults. Additional genetic lesions led to the most recent WHO classification that allows stratification in four tumor entities, mIDH gliomas [Oligodendrogliomas (OD) and Astrocytomas (AA)], and wtIDH gliomas: [Glioblastoma (GBM)-like and GBM]. While mIDH clearly correlates with better prognosis, the role of this mutation in antitumor immunity remains controversial. First, we predicted the level of infiltrating immune and stroma cells by ESTIMATE scores and both were significantly lower in mIDH patients. We also found reduced expression of immunoregulatory genes (PD-LI, PD-1, CTLA-4, IDO1, IL-10, LAG3 and TIM3) in mIDH biopsies (p
