«Characterization of Biodegradable In Situ Formed and Preformed Microspheres»

RODOLFO N. MARIANO; LUDMILA N. TURINO; MARÍA I. CABRERA; RICARDO J. A. GRAU

Córdoba (Argentina)

Congreso; RICIFA 2010, 1º Reunión Internacional de Ciencias Farmacéuticas; 2010

Dpto de Farmacia. FCQ (UNC)-Dpto Farmacia. FCByF (UNR)

Biocompatible and biodegradable poly(lactic-co-glycolic) acid (PLGA) are widely used for controlled release technology. Microspheres are a novel pharmaceutical dosage form of the PLGA-based release devices (1). They can be injected as an as emulsion or as a suspension of preformed microspheres, depending on its manufacturing process. In both cases the polymer and the drug are dissolved in a solvent-system (phase 1) and then emulsified within a second solvent-system (phase 2). For in situ formed microsphere (ISM), the precipitation occurs when this emulsion comes in contact with physiological fluids and biocompatible organic Phase 1 is diluted. For preformed microspheres (PFM), the volatile no-biocompatible Phase 1 is eliminated in laboratory controlled conditions from the emulsion to precipitate the polymer in phase 2 (2, 3). As previous work to develop a drug-eluting platform, we perform an experimental study to analyze the microscopic characteristic of both systems to choose the most appropriate formulation.