ROR1 PROMOTES MELANOMA CELL SURVIVAL BY UPREGULATING STAT3-DEPENDENT REGULATION OF BCL2-FAMILY PROTEINS

QUEZADA MJ; MASCOLO P; BARRAZA, JESUS; LOPEZ BERGAMI P

Mar del Plata

Congreso; Reunión Anual de Sociedades de Biociencias 2022; 2022

Sociedad Argentina de Investigacion Clinica

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a tyrosine kinase receptor that play crucial roles in the development of various organs and tissues as well as in human disease. ROR1 is overexpressed in cancer and has been associated with cellular features that promote malignancy, namely cell proliferation, survival, migration/invasion. The role of ROR1 in melanoma has not been investigated to a great extent. The aim of this work is to study the role of ROR1 in melanoma cell survival. To this end, both gain- and loss-of-function approaches were employed by generating A375 cell lines with both overexpression and silencing of ROR1. Overexpression of ROR1 significantly increased the expression levels of several of the anti-apoptotic members of the Bcl2 family including Bcl2, Mcl1, Bcl-XL and Bcl2L10 (P