Keratoconus Diagnostic Model Integrating Ocular Response Analyzer Measurements and Corneal Topography

RUISEÑOR VÁZQUEZ PABLO; NEBOT LISANDRO; FUENTES BONTHOUX FERNANDO; DELRIVO MARIANELLA; PFÖRTNER TOMÁS; GALLETTI JEREMÍAS GASTÓN

Fort Lauderdale, FL

Congreso; ARVO 2012 Annual Meeting; 2012

ARVO

Purpose:To evaluate the performance of a diagnostic model for keratoconus that considers both Ocular Response Analyzer (ORA) parameters and corneal topography, in order to improve the yield with myopic eyes. Methods:95 eyes from 95 healthy subjects in group 1 and 70 eyes from 70 keratoconus patients in group 2 were evaluated with Ocular Response Analyzer (ORA), corneal topography, aberrometry and anterior segment optical coherence tomography for central corneal thickness (CCT) measurement. For group 1, an eye with spherical equivalent < -5.00 was considered myopic and for group 2, the eye with the lowest average corneal power (ACP) was chosen. Corneal hysteresis (CH) and resistance factor (CRF) transformations to compensate for CCT effect (DifCH, DifCRF and CH-CRF) and diagnostic cutoff points were obtained from previous work on an independent sample. Discriminant functions were built using biomechanical variables and ACP. Results:Group 2 eyes had lower CCT (μm, 516.6±35.87 vs 491.6±31.92, p