Cofilin-1 levels and intracellular localization are associated with prognosis of melanoma

BRACALENTE, CANDELARIA; RINFLERCH, ADRIANA R.; GARCÍA, FRANCISCO M.; IBAÑEZ, IRENE L.; VOLONTERI, VICTORIA; GALIMBERTI, GASTÓN N.; KLAMT, FABIO; DURÁN, HEBE

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias, LXII Reunión Anual de la Sociedad Argentina de Investigación Clínica; 2017

Sociedad Argentina de Investigación Clínica

Melanoma is an aggressive cancer with highly metastatic ability. We propose cofilin-1, a key protein in the regulation of actin dynamics and migration, as a prognostic marker. We determined cofilin-1 levels in a retrospective cohort of patients with melanomas and benign lesions of melanocytes (nevi) by immunohistochemistry. Results show a significant association between high levels of cofilin-1 and tumor malignant features, such as advanced stages of malignant melanoma (MM) (p