(512) ASSESSMENT OF JAWBONE MICROARCHITECTURE IN BISPHOSPHONATE- TREATED SHEEP BY CONE-BEAM COMPUTED TOMOGRAPHY

AVENDAÑO, MARIA EUGENIA; POLETTO ADRIANA; DAVISON, MARIO RICARDO; BONANNO MARINA SOLEDAD; ZENI, SUSANA NOEMÍ

CABA

Congreso; Reunión Anual de Sociedades de Biociencia; 2020

SAIC SAI SAFIS

The cone-beam computed tomography (CBCT) is a non-invasive 3D reconstruction technique that enables to assess jawbone micro-architecture. It is used to illustrate results through 3D images. In the present report, the combination of CBCT with other techniques was used to evaluate changes in composition and micro-architectural structure quantity of the ewe jawbone after oestrogen withdrawal (OVX) and/or chronic treatment with high doses of zoledronic acid (zol). Three groups of adult Corriedale ewes, 35 to 40 kg body weight were used: OVX: OVX ewes receiving saline solution; ZOL: OVX ewes treated with Zol (4 mg/month) for 28 months for high cumulative dose of ZOL in bones and SHAM: SHAM ewes receiving saline solution (control). At the end of the study, hemi-mandibles were extracted: Bone mineral density (BMD) and content (BMC) of the mandibles were evaluated ex vivo by DXA (Lunar DPX); CBCT was performed using Planmeca Promax 3D Classic. Results of CBCT: OVX as compared to SHAM ewes significantly decreased BMC and BMD (p