INHALATION AIR POLLUTANTS IMPAIR THE LUNG ANTIOXIDANT SYSTEM INVOLVED IN ALVEOLAR BARRIER INJURY REPAIR RESULTING IN OXIDATIVE DAMAGE

REYNOSO SOFIA; FREIRE AGUSTINA; MARIANA GARCES; CACERES LOURDES; FLORENCIA SARNO; MARCHINI TIMOTEO; EVELSON PABLO; MAGNANI NATALIA

Congreso; LXVII Reunión anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2022

It has been suggested that breathing polluted air leads to pulmonaryoxidative stress and inflammation which might affect tissue damagerepair mechanisms. The aim of our work was to study if exposure toBuenos Aires urban air impairs lung antioxidant system activity shifting the cell redox metabolism to a more oxidase status, which couldbe associated with a delayed injury repair. In order to address suchmechanisms, BALB/c mice were exposed to filtered air (FA) or urbanair (UA) from Buenos Aires City, in whole-body exposure chambersfor up to 8 weeks. Then, moderate lung injury was induced by intratracheal instillation of 0.1 N hydrochloric acid (HCl). Samples wereevaluated 5 days after HCl treatment. Regarding the antioxidantsystem, even though transcription factor Nrf2 expression was higherin the UA+HCl group (p