THIOREDOXIN OVEREXPRESSION SHOWS CARDIOPROTECTION AGAINST THE REDOX METABOLISMS ALTERATIONS INITIATED BY AIR POLLUTION EXPOSURE

MARIANA GARCES; MAGNANI NATALIA; PEREZ VIRGINIA; CACERES LOURDES; FREIRE AGUSTINA; YEISON TRIGUERO; ÁLVAREZ SILVIA; GELPI RICARDO; DANNUNZIO VERONICA; EVELSON PABLO

Congreso; LXVII Reunión anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2022

Epidemiological studies showed correlations between daily changesin particulate matter (PM) concentration and cardiovascular diseases such as heart failure. Reactive O2 species (ROS) production triggered by PM exposure can initiate oxidative damage mechanisms.Thioredoxin (Trx) is part of an antioxidant system that maintainsredox homeostasis; nevertheless, their role after air PM is still unknown. The aim of this work was to analyze the cardioprotectiveeffect of selective overexpression of thioredoxin 1 (Trx1) in a micemodel of acute exposure to residual oil fly ash (ROFA). Wild type(Wt) and Trx1 mice were intranasally instilled with a ROFA suspension (1 mg/kg body weight). Saline solution was used as a control.Impaired contractile reserve and lusitropic reserve were observedon Wt mice exposed to ROFA (p