URBAN AIR INDUCES OXIDATIVE STRESS, INFLAMMATION AND DAMAGE OVER TIME IN MICE OLFACTORY BULB

FREIRE AGUSTINA; MARIANA GARCES; CACERES LOURDES; REYNOSO SOFIA; MARCHINI TIMOTEO; OCTAVIO DIANA; MARTINEFSKI, MANUELA; TRIPODI, VALERIA; ALVAREZ, SILVIA; CALABRÓ VALERIA; MAGNANI NATALIA; EVELSON PABLO

Congreso; LXVII Reunión anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2022

Growing evidence support the notion that the central nervous system(CNS) is a highly relevant target of air particulate matter (PM). Oxidative stress and neuroinflammation are suggested to play a majorrole in the neurotoxicity after PM inhalation. In order to address suchmechanisms, the aim of this work was to study the chronic effects ofurban air on mice olfactory bulb (OB), focusing on oxidative stressand inflammation markers over time. Balb/C 8-week-old mice wereexposed to filtered air (FA, control group) or urban air (UA) in wholebody chambers for up to 4 weeks. Regarding OB redox status, UAexposed mice showed a decreased reduced glutathione level (GSH)(p