ALTERATIONS IN EPITHELIAL CADHERIN AND FXYD5/DYSADHERIN EXPRESSION IN COLORECTAL CANCER PROGRESSION AND METASTASIS

LLEYDA MICAELA; MENDEZ-BRITO, SANDRA; BERNACCHIA JULIANA LOURDES; COSTAS M. A.; VAZQUEZ LEVIN MÓNICA

Congreso; Reunión Anual de Sociedades de Biociencias; 2022

Colorectal cancer (CRC) is the most common malignant diseaseof the digestive tract, and 2nd in incidence/mortality worldwide andin Argentina. Epithelial Cadherin (Ecad) loss has been related tocell adhesion loss, migration and invasiveness. FXYD5/Dysadherin(FXYD5) was found associated with tumor aggressiveness/metastasis in solid tumors and is a negative Ecad modulator. Studieswere initiated to characterize Ecad and FXYD5 expression inCRC and their role in tumor progression/metastasis. Transcriptexpression analysis was done in datasets from colon adenomaand CRC patient’s and cell lines (GEO; TCGA). Paired adenomas/normal tissue analysis (GSE8671; n=32) revealed decreasedECad (NT=20,884±3,342; A=16,855±2,082) and increased FXYD5(NT=1,107±435; A=3,577±1,193) (p