DIRECT ACTION OF INTESTINAL MICROORGANISMS IN COLORECTAL CANCER CELL LINE

BERNACCHIA JULIANA LOURDES; PALMA, ALEJANDRA GRACIELA; LIRA, MARÍA CECILIA; ROSA, FRANCISCO DAMIÁN; DE PAULIS ADRIANA; LAUDANNO OSCAR; LLEYDA MICAELA; NOWICKI, SUSANA; VAZQUEZ LEVIN MÓNICA; RUBIO M. FERNANDA; COSTAS M. A

Congreso; Reunión Anual de Sociedades de Biociencias; 2022

Numerous evidence demonstrate the importance of the microbiomemainly due to its immunological action, in the development ofmultiple diseases, such as colorectal cancer (CRC). In agreementwith previous works, bacteria such as Escherichia coli (E.coli) andBacteroides fragilis, among others, have high prevalence in CRCpatients compared to the normal population. In this work we investigatethe possible pathways and signaling that may contribute toCRC development that could be affected by direct action of bacteriaover colorectal cancer cells, in the absence of additional signalsfrom the immune system. Therefore, we first determined the totalamount of genes that were up or down regulated (log FC >1 or 4, thus, strongly involved in CRC.We conclude, there are signals and pathways independent of theimmune system that could be induced directly by bacteria in the epithelialcolorectal cells, contributing to CRC.