(89) RESORBED ALVEOLAR BONE RECOVERY BY TREATMENT WITH PTH 1-34 AT LOW DOSES IN EXPERIMENTAL PERIODONTITIS

BONANNO MARINA SOLEDAD; ZENI CORONEL, ESTEFANÍA MAGALÍ; SEIJO, MARIANA; BIDEVICH, NICOLÁS; AVENDAÑO, MARIA EUGENIA; PRELIASCO, MARIANA; DAVISON, MARIO RICARDO; ZENI SUSANA NOEMÍ

Mar del Plata

Congreso; Reunión Anual de Sociedades de Biociencia; 2022

Sociedad Argentina de Investigación Clínica

RESORBED ALVEOLAR BONE RECOVERY BY TREATMENT WITH PTH 1-34 AT LOW DOSES IN EXPERIMENTAL PERIODONTITISWe compared two low doses of PTH for the recovery of alveolar bone loss by experimental periodontitis.Periodontitis was induced in 18 female Wistar rats (221±15g); 96 hours later, rats were divided and treated by injection into the gingival sulcus: G1: saline solution (SS), G2 and G3 with 0.2 or 0,4 µg PTH 1-34/Kg/3 times a week. A control group (C) (n=5) without ligature was injected with SS. After 21 days, serum was extracted to determine CrossLapp (CTX), osteocalcin (OCN) and PTH by ELISA. Animals were euthanized and hemimandibles (HM) and tibias (T) were extracted for histomorphometry (percent bone volume: BV/TB% and periodontal space height: PSA).Results (C, G1, G2 y G3 respectively. Mean±SD, different letters indicate p