Parirenal white adipose tissue browning, contributes to tumor development in kindney cancer

FERRANDO MATIAS; BRUNA, FLAVIA A.; LEONARDO, ROMEO; DAIANA, MOYA; GOMEZ SE; CARON RW; TONEATTO, JUDITH; PISTONE-CREDYT V

BUENOS AIRES

Congreso; SAIC; 2021

SAIC. SAI. SAFIS

Renal cancer (CaR) is considered the fifth most common type of cancer worldwide and is associated with highmortality rates in men and women. In Argentina it is estimated that there are 4100 new cases per year in both sexes,being more frequent in men. In tumor development and maintenance of a cancerous phenotype, bidirectionalcommunication between epithelial cells and stromal environment is necessary. Among the different types of cellssurrounding renal epithelial cells, renal adipose tissue is one of the most abundant. The adipose tissue is a bioactiveendocrine organ that not only secretes soluble factors but also contributes significantly to the composition of theextracellular matrix. Recently we observed that hRAT (human adipose tissue from renal cell carcinoma) expressessignificantly higher amounts of leptin and ObR, relative to hRAN (human adipose tissue from normal kidney). It hasbeen shown that leptin has a pro-tumorigenic function.