La sobreexpresión de Trx muestra un efecto cardioprotector contra las alteraciones del metabolismo redox iniciadas por exposición a la contaminación ambiental

MARIANA GARCES

Simposio; Simposio 30 años instituto de fisiopatología cardiovascular; 2022

Epidemiological studies showed correlations between daily changes in particulate matter (PM) concentration and cardiovascular diseases such as heart failure. Reactive O2 species (ROS) production triggered by PM exposure can initiate oxidative damage mechanisms. Thioredoxin (Trx) is part of an antioxidant system that maintains redox homeostasis; nevertheless, their role after air PM is still unknown. The aim of this work was to analyze the cardioprotective effect of selective overexpression of thioredoxin 1 (Trx1) in a mice model of acute exposure to residual oil fly ash (ROFA). Wild type (Wt) and Trx1 mice were intranasally instilled with a ROFA suspension (1 mg/kg body weight). Saline solution was used as a control. Impaired contractile reserve and lusitropic reserve were observed on Wt mice exposed to ROFA (p