Longitudinal humoral immune response against adenovirus-based COVID-19 vaccines in patients with Multiple Sclerosis from Argentina undergoing immunosuppressive treatment

SILVA, BERENICE; MIGLIETTA, ESTEBAN; CASABONA, JUAN CRUZ; PITOSSI, FERNANDO J.

Amsterdam

Congreso; ECTRIMS 2022; 2022

European Committee for Treatment and Research in Multiple Sclerosis

Introduction: Diseases modifying therapies (DMTs) in people with Multiple Sclerosis (pwMS) can alter the immune response to SARS COV2 vaccines. Most of the reports related to the humoral immune response to SCvac under different DMTs were performed on RNA-based, but not on adenoviral vaccines.Objective: to analyze the longitudinal humoral immune responses to adenovirus-based vaccines (Sputnik V and AZD1222)  in pwMS under different diseases modifying therapies (DMTs)