INHIBITION OF LIPID PEROXIDATION BY CANNABIS SATIVA AND LARREA DIVARICATA EXTRACTS AND THEIR COMBINATION

SAINT MARTIN, MALEN; PERALTA, IGNACIO; SILVA SOFRÁS FRESIA; COGOI, LAURA; VAN BAREN CATALINA; ALONSO MARÍA ROSARIO; ANESINI, CLAUDIA

Ciudad Autónoma de Buenos Aires

Congreso; 53º Reunión Anual SAFE; 2021

Sociedad Argentina de Farmacología Experimental

Oxidative stress, through lipid peroxidation, affects central nervous system altering cognitive functioning during epilepsy. Cannabis sativa L. (Cannabaceae) is a medicinal plant used as anticonvulsant, being cannabidiol (CBD) its main anticonvulsant agent. Larrea divaricata Cav. (Zygophylliaceae) is an autochthonous plant with antioxidant activity. The aim of this work was to study the synergistic effect of an ethanolic extract of C. sativa (CSR) and an aqueous extractof L. divaricata (LE) on inhibition of lipid peroxidation to improve the therapeutic outcomes. The participation of CBD and nordihydroguaiaretic acid (NDGA) was evaluated.