The serum uric acid/creatinine ratio is associated with nonalcoholic fatty liver disease (NAFLD) in the US general population

CARLOS JOSE PIROLA; SILVIA SOOKOIAN

Anaheim

Congreso; The Liver Meeting 2021; 2021

The American Association for the Study of Liver Diseases

Background: Previous studies suggested that the serum uric acid-to-creatinine ratio (sUA/Cr) is associated with metabolic syndrome components, but there is limited evidence of a relationship between sUA/Cr and NAFLD. Here, we investigated the association between serum uric acid/creatinine ratio (sUA/Cr) and NAFLD.Methods: We performed a cross-sectional analysis in 3359 subjects who participated in the NHANES 2017-2018 survey and consumed less than 30 and 20 g alcohol for men and women, respectively, with no positive tests of viral hepatitis. Liver steatosis was defined by a controlled attenuation parameter (CAP) >268 dB/m obtained via transient elastography as the threshold for significant steatosis. We modeled the relationship between NAFLD and relevant demographic,anthropometric, and biochemical factors (Table) by LASSO logit regression. We performed a logistic regression analysis to investigate the included variables associated with NAFLD, and an adjusted odds ratio (OR) of sUA/Cr for NAFLD was estimated. We modeled a NAFLD score using multivariate regression results. ROC analyses evaluated NAFLD prediction sensitivity and specificity. All calculations were performed in STATA 16.0.Results: sUA/Cr was significantly higher in participants with NAFLD than in those without NAFLD (Table). LASSO logit regression showed that only logarithmized age (p