INVESTIGADORES
GUELMAN Laura Ruth
congresos y reuniones científicas
Título:
NEUROPROTECTIVE EFFECT OF 17ßESTRADIOL IN A RAT MODEL OF NEONATAL X RADIATION
Autor/es:
CACERES, L.G; AÓN, L; SARACENO, E; URAN, S.L; CAPANI, F; GUELMAN, L.
Lugar:
Bexco, Busan, Korea
Reunión:
Congreso; 22nd Biennial Meeting of the ISN/APSN Joint Meeting; 2009
Institución organizadora:
ISN/APSN
Resumen:
Developing Central Nervous System is vulnerable to radiationinduced
reactive oxygen species (ROS). The consequent oxidative
stress has been shown to produce changes at behavioral,
biochemical and histological levels in cerebellum (CE) and
hippocampus (HIP).
The aim of the present work was to test if 17 â-estradiol, a potential
neuroprotector, was able to counteract these changes.
Neonatal male Wistar rats were X-irradiated (5 Gy) in their cephalic
ends up to 48hs of postnatal life and a group of this animals was
treated with 17â-estradiol (5 ìg/g). Open field (OF) test and ROS
levels, as well as a histological assessment, were performed at 30
postnatal days.
Administration of 17 â-estradiol improved the short-term
habituation and decreased the time spent in the centre in the OF.
ROS levels returned to control in HIP and the cytoarchitecture of
CE was reconstituted.
These results suggest that 17 â-estradiol was able to counteract the
effects of X-rays at behavioral, biochemical and histological levels,
probably acting through an antioxidant mechanism.