Canonical and Non-canonical Function of EZH2 in Progesterone Receptor Target Genes in Breast Cancer

MARTINA BELMONTE, AGUSTINA ROLDAN DEAMICIS, FLORENCIA MERCOGLIANO, SANTIAGO MADERA, FLORENCIA MAURO, MAURO CENCIARINI, SOFIA BRUNI, ROSALÍA CORDO RUSSO, ROXANA SCHILLACI, PATRICIA V ELIZALDE,CECILIA PROIETTI.

Atlanta

Congreso; 104th Annual Meeting of the Endocrine Society.; 2022

Enhancer of Zeste homolog 2 (EZH2) is a histone methyltransferase which catalyzes the trimethylation of lysine 27 of histone H3 (H3K27me3), an epigenetic mark associated with chromatin compaction and transcriptional repression of target genes. EZH2 can also act in a non-canonical function by regulating transcription independently of its enzymatic activity. Since EZH2 has been implicated in the progression of several types of cancer, including those of the breast, and our own previous results indicate that EZH2 is required for progestin-induced breast cancer growth, we hypothesized that EZH2 could function as a mediator in the pro-tumorigenic effects of progestins, targeting specific tumor suppressor and differentiating genes to allow ER/PR-positive BC growth