Effect of pH on cephalexin adsorption using mesoporous silica

KIARA MONTIEL-CENTENO; DEICY BARRERA; ELBIO SAIDMAN; LESLIE ARAGÓN; DEICY BARRERA-DIAZ, M. MOLANO, G.CAMARGO, J.C. MORENO-PIRAJÁN, L. GIRALDO-GUTIERRÉZ, KARIM SAPAG

Fortaleza

Congreso; 13° Brazilian Meeting on Adsorption (EBA13); 2020

The effect of pH on the aqueous adsorption of cephalexin (CFX) was studied using as an adsorbent an ordered mesoporous silica materials of the SBA-15 type. This materials was synthesized and subsequently characterized by different techniques such as adsorption-desorption from N2 at 77 K, FTIR, SEM and point zero charge. Different interesting textural and chemical properties were found to carry out drugs adsorption process. CFX adsorption assays were performed at different pH values (1.3-10.3), adsorbed amount were quantified by UV-Vis. The SBA-15 material was again characterized after adsorption of CFX. It was found that pH has a strong influence on adsorption capacity of this drug, which is closely related to the charge density of the adsorbent material as well the distribution of the species of the CFX molecule and the textural properties of the adsorbent.