EFECTOS SUBLETALES DE NANOPARTÍCULAS DE BASE γ-ALÚMINA EN CNESTERODON DECEMMACULATUS

SVARTZ GABRIELA; ARONZON CAROLINA; PEREZ CATAN S; PEREZ COLL S

Virtual

Congreso; XXXVII Congreso Interamericano virtual de Ingeniería Sanitaria y Ambiental de AIDIS; 2021

The use of nanomaterials (NMs) has exponentially grown due to the large number of applications in industrial, pharmaceutical and medical areas. That is the case of alumina (Al) nanoparticles which are extensively used as support in heterogeneous catalysis processes, reach environment and biota and can cause great toxicity because of their ubiquitous properties, such as extremely small size and high specific surface area. Although there is no data about the concentrations of these NMs in the environment, it is required to assess the potential deleterious effects of these NMs on living organisms to prevent toxicity also at population level. In the present study, it was analyzed the oxidative stress of a nanoceramic catalyst, Ni/γ-Al2O3 (NC) and the NMs involved in its synthesis, γ-Al2O3 support (SPC) and NiO/γ-Al2O3 precursor (PC), on the autochthonous fish Cnesterodon decemmaculatus. Young adult fish of this species were exposed to 50 and 100 mg/L of each NMs for 96 h and biomarkers of oxidative stress and neurotoxicity were measured. The results indicated an inhibition of glutathione S-transferase activity in all treatments, and alterations in the activity of catalase and superoxide dismutase. There were no significant variations in TBARs levels (lipid peroxidation). Moreover, exposure to the three NMs caused inhibition of acetylcholinesterase activity. Based on present study, it suggests that these NMs can cause major problems by inducing oxidative stress and causing neurotoxicity in C. decemmaculatus and this could lead to depletion of fish populations in freshwater ecosystems.