Functional characterization of the bacterioferritin comigratory protein B of Mycobacterium tuberculosis

MARCELO REYES; MARTIN HUGO; DIEGO SEBASTIAN VAZQUEZ; JAVIER SANTOS; RADI, RAFAEL; TRUJILLO, MADIA

Ciudad Autónoma de Buenos Aires

Congreso; VIII Meeting of the Society Free Radical Biology and Medicine/South American Group (SFRBM-SAG); 2013

SFRB

The Mycobacterium causative agent of tuberculosis (TB), is an extremely successful intracellular pathogen, able to proliferate inside thephagosomes of activated macrophages, where it is exposed to cytotoxic peroxides. Mt expresses a catalase-peroxidase heme peroxidase and five peroxiredoxins (Prx). Two of these were classified as bacterioferritin comigratory proteins (MtBcpB and MtBcp), but its function as peroxidases has not been experimentally tested. In this work, we propose to perform a functional and physicochemical characterization of MtBcpB.