Argentine real world data experience on gene mutation profiling panels in Acute Myeloid Leukemia

LINCANGO YUPANKI, MARCO; ASINARI, MARIANA; ZEBALLOS, MAXIMILIANO; JAUK, FEDERICO; RAHHAL, MARILINA; ZANELLA, LORENA; GIERE, ISABEL; MELA OSORIO, MARIA JOSE; ZUBIETA, MARTIN; GIMENEZ CONCA, ALBERTO; AGRIELLO, EVANGELINA; NAVICKAS, ALICIA; CASTRO, MARÍA BELEN; ARBELBIDE, JORGE; BASQUIERA, ANA L; BELLI, CAROLINA

Virtual

Congreso; 26th Congress of the European Hematology Association; 2021

European Haematology Association

BackgroundSequencing data from patients with Acute Myeloid Leukemia (AML) constitute a significant guidance at prognostic and therapeutic stages to support clinical decision making. In Argentina, next generation sequencing (NGS) on hematological diseases is performed in few institutions and the experience is currently based on small cohorts of patients. We have organized a collaborative working group in an effort to interactively increase the knowledge in our media.AimsTo evaluate NGS real-world data from AML patients in a multicenter Argentine study. MethodsSequencing and clinical data of 90 adult AML patients were gathered from five centers performing NGS located across Argentina. Data was analyzed by using R-bioconductor (v4.0.3) and SPSS software. Statistical analyzes included Fisher?s exact /Chi2 and Kaplan Meir/Log-rank test. Median values are presented with interquartile ranges, unless otherwise specified. P values