Circadian biomarkers in asymptomatic offspring of patients with late-onset Alzheimer's disease and their relationship with cognitive performance

ABULAFIA, CAROLINA; DUARTE ABRITTA, BARBARA; SÁNCHEZ, STELLA-MARIS; VILLARREAL, MIRTA F.; DE GUEVARA, M. SOLEDAD LADRON; SEVLEVER, GUSTAVO; FIORENTINI, LETICIA; GUINJOAN, SALVADOR M; VIGO, DANIEL E

Congreso; word sleep congress; 2019

Early neuropathological changes characteristic of late-onset Alzheimer´s disease (LOAD) impact structures that regulate circadian rhythms and particularly sleep. Indeed, sleep pattern is emerging as a potential biomarker, mechanistic pathway and treatment target in LOAD. We hypothesized that circadian rhythm anomalies would already be present in asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) prior to cognitive decline.