INGEBI 02650
INSTITUTO DE INVESTIGACIONES EN INGENIERIA GENETICA Y BIOLOGIA MOLECULAR "DR. HECTOR N TORRES"
Unidad Ejecutora - UE
capítulos de libros
Título:
The Efficiency of Multi-target Drugs: A Network Approach
Autor/es:
ALAN TALEVI; LUCAS N. ALBERCA
Libro:
Approaching Complex Diseases
Editorial:
Springer
Referencias:
Año: 2020; p. 63 - 75
Resumen:
Multi-target agents have attracted great attention in the last 15 years, as they are expected to provide more efficacious and safer therapeutic solutions, less prone to drug resistance phenomena. They thus seem particularly valuable in the fields of complex disorders and infectious diseases. We discuss the generalities of tailored multi-target drug design, including target combination choice, optimization of potency ratio to the different targets, peculiarities of computer-guided drug discovery and design considerations.
