Inflammatory mediators involved in early pregnancy loss

AISEMBERG J; VERCELLI C; OGANDO D; BILLI S; FRANCHI AM

Inflammatory mediators involved in normal and pathological pregnancies

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Lugar: Kerala, India; Año: 2009;

Although there has been some progress in the understanding of the cause of early pregnancy loss due to chromosomal abnormalities, there is a dearth of knowledge of the causes of isolated and recurrent loss in euploid conceptuses. We revised the role of several inflammatory agents in the mechanism of early pregnancy loss. Genital tract bacterial infections could induce abortion and are some of the most common complications of pregnancy; however, the mechanisms remain unclear. In the early pregnancy, low doses of lipopolyssacharide (LPS) that reproduce most of the systemic and cellular effects of sepsis, without affecting maternal survival, produce high percentage of embryonic resorption (ER). It was demonstrated that nitric oxide (NO) and prostaglandins (PG) are involved in the ER, observing augmented production of these molecules and that inhibitors of their synthesis could prevent ER. Also, it has been observed an increase in the oxidative damage, evidenced by nitration of tyrosine proteins, due to the peroxynitrite anion. These results suggest that several inflammatory molecules could participate in the mechanism of early pregnancy and that their modulation could be useful tools to prevent early pregnancy loss.