Sequential histopathological and oxidative damage in different organs in choline deficient rats

REPETTO, MARISA; OSSANI, GEORGINA

Free Radical Pathophysiology

Transworld Research Network.

Lugar: Kerala; Año: 2008; p. 433 - 450

Choline-deficiency (CD) produces liver pathology (steatosis, cellular death, cirrhosis and cancer); heart changes (necrosis), brain damage and acute renal failure with morphological features that vary from focal tubular necrosis to widespread cortical necrosis. Alterations in choline transport and metabolism have been involved in a number of neurodegenerative disorders such as Alzheimer´s and Parkinson´s diseases. Oxidative damage is a pathogenic mechanism involved in the development of the lesions induced by choline-deficiency that produces oxidative damage in liver, heart, kidney and brain by lipid peroxidation, decrease of total endogenous intracellular and systemic antioxidants, and consumption of tissue alpha-tocopherol. The organ first affected by choline-deficiency is the liver that responds with steatosis. In the other organs, lipid peroxidation is previous to the morphological damage. The peroxidation of plasmatic lipids is previous to the oxidative and morphological damage of the organs affected by choline-deficiency and TBARS is an early marker of lipid peroxidation in plasma and tissues.